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The hemp market has changed fast. After the 2018 Farm Bill, many companies began selling intoxicating cannabinoids that are often marketed as “hemp-derived,” “legal THC,” or “alternatives” to Delta-9 THC (the main psychoactive/intoxicating component). Some of these compounds exist naturally in Cannabis sativa L. in trace amounts. Others are created through chemical conversion from hemp-derived CBD or other cannabinoids. Chemical processes include Isomerization (conversion of

A clinician’s look at emerging evidence, formulation design, and responsible product development Why Sleep Matters More Than Ever Sleep is not simply rest — it is recovery. It is when the body recalibrates hormones, consolidates memory, regulates immune function, and restores physical and mental energy. Yet millions of adults report difficulty falling asleep, staying asleep, or waking feeling restored. Because of this, researchers around the world are studying how the endocan

A Clinician’s Perspective from Dr. Murse | CannabisDNP A recent peer-reviewed clinical study titled: “Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial” Published: 29 September 2025 examined the safety and outcomes of a standardized cannabis-derived formulation in adults living with chronic low back pain — one of the most common conditions affecting quality of life worldwide. This study is notable not on

By Jesse Cole Christianson, DNP, APRN, AGPCNP-BC | cannabisdnp.com Educational only. Not medical advice. These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Adult use only (21+). Have you ever been completely exhausted — but your brain just won't shut off? You're lying in bed. Your body is tired. But your mind is running a mile a minute. You look at the clock. It's 2 a.m. Then 3 a.m. Then 4 a.m. Sound familiar? H

By Jesse Cole Christianson, DNP, APRN, AGPCNP-BC | cannabisdnp.com Educational only. Not medical advice. These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. If you've ever lain awake at 2 a.m. with a racing mind and an exhausted body, you already understand what researchers now confirm clinically: insomnia isn't a sleep problem. It's a brain arousal problem. The circuits that are supposed to power down stay stubb

Written by Jesse Cole Christianson, DNP, APRN, AGPCNP-BC Board-Certified Nurse Practitioner | Cannabinoid Science Educator | Founder, Dr. Murse/CannabisDNP If you've ever felt your heart racing before a big presentation, or found yourself lying awake at 2am replaying a conversation from three days ago — you already know what anxiety feels like in your body. What you might not know is that your brain has a built-in system designed to calm that response down. And that system i

Chronic pain affects roughly 50 million Americans. If you're one of them, you've probably been told to try this medication, avoid that activity, or just "manage" it — without much explanation of what's actually happening in your body. Here's what the research says. Be mindful that DOSE AND ROUTE OF ADMINISTRATION MATTERS. The Hidden Pain System You Were Born With Your body has a built-in network for managing pain signals called the endocannabinoid system (ECS) . It works thro

Written by Jesse Cole Christianson, DNP, APRN, AGPCNP-BC Cannabinoid Science Educator | Founder, Dr. Murse/CannabisDNP Cannabinoids have captured a lot of attention lately — and for good reason. These plant-based compounds are among the most actively studied natural molecules in modern science. But what actually goes into creating a thoughtful cannabinoid formulation? How do evidence-informed practitioners ensure these products are both well-crafted and responsibly made? As

Cannabinoids have stepped into the spotlight in plant-based wellness — and for good reason. These compounds, found in the cannabis plant, interact with one of the body’s most important regulatory networks: the endocannabinoid system (ECS). But here’s what most people miss: Not all cannabinoid products are created equally. The difference isn’t hype.It ’s formulation. At Dr. Murse / CannabisDNP , we focus on what we call clinical cannabinoid formulations — precision-designed b

Migraines are complex neurobiological events — not simply “bad headaches.” They involve dysregulation of pain pathways, vascular signaling, neuroinflammation, and neurotransmitter systems. One emerging area of interest in migraine research is the endocannabinoid system (ECS) — the body’s intrinsic regulatory network that helps modulate pain, mood, inflammation, and neuronal excitability. As a clinician focused on cannabinoid science, I want to walk you through what current r

Cannabis has come a long way from its early days of stigma and misunderstanding. Today, thanks to advances in science and medicine, we’re unlocking the true potential of cannabis through clinical cannabis formulations . These carefully crafted products offer a new level of precision and reliability for those seeking plant-based wellness alternatives. If you’ve ever wondered how cannabis can fit into your daily routine for balance, calm, or rest, this post is for you. Let’s di

Educational content only. Not medical advice. Cannabinoid therapy should always be personalized and discussed with a qualified healthcare professional, especially when considering current medications, past medical history, or complex medical conditions. At Dr. Murse / CannabisDNP , we approach cannabinoid therapeutics the same way we approach primary care: individualized, clinically informed, and intentionally dosed . Cannabinoids are not a one-size-fits-all solution—and they

Written by Jesse Cole Christianson, DNP, APRN, AGPCNP-BC Cannabinoid Science Educator | Founder, Dr. Murse/CannabisDNP When I first started exploring wellness alternatives, cannabinoids caught my attention based on their safety profiles and the growing volume of focused research available. These compounds — derived from Cannabis sativa L. — are among the most actively studied natural compounds in modern science. But what exactly are cannabinoids, and how do they interact wit

Writer: Jesse Christianson | Jan 24 | 4 min read When it comes to exploring plant-based wellness, hemp cannabinoid formulations offer a fascinating and promising path. You might have heard about cannabinoids like CBD and THC, but understanding how these compounds are thoughtfully formulated can make all the difference in your wellness journey. Let's dive into what hemp cannabinoid formulations are, how they work, and why they might complement your daily routine. What Are Some

Last time, we talked about how the endocannabinoidome (that’s “endo-can-nuh-bin-OH-dome”) includes a huge network of receptors, signaling molecules, and enzymes that help keep your body balanced. It is larger than the endocannabinoid system that we hear so much about. Now, let’s take it a step further and talk about how everything works together — because the endocannabinoidome isn’t just a bunch of random parts doing their own thing. It’s more like an orchestra, with every i

Photographer Markus Reugels uses high-speed photography to capture these images of falling droplets. (Image credit: Markus Reugels, LiquidArt ) Now that we’ve talked about some of the main cannabinoids (like THC and CBD), how they work together, and the key receptors that help them do their job — it’s time to go a little deeper. Today, we’re stepping into something called the endocannabinoidome . That’s a big word, but it simply means the entire network of receptors, signalin

As stated in the previous blog, Let's build on our knowledgea and see how phytocannabinoids can be useful! Our bodies have a built-in...

(Image courtesy of the Canadian Consortium for the Investigation of Cannabinoids) Cannabinoid receptor type 1 (CB1) lives mostly in the...

Fundamental Representation Almeida, C. F., Teixeira, N., Correia-da-Silva, G., & Amaral, C. (2022)....

Image by NIDA (NIH) Did you know your body makes its own natural “cannabis-like” chemicals? One of the most fascinating is anandamide ,...